New research Oct 2017 study (The Vitamin B6 Paradox) on Researchgate showed that taking the pyridoxine form of b6 in larger doses actually leads to decreased vitamin b6 function and symptoms of deficiency. The inactive form pyridoxine competitively inhibits the active pyridoxal-5-phosphate form and both pyridoxal 5 phosphate dependent enzymes were inhibited by pyridoxine. So the more pyridoxine you take, the more it can work against you and even lead to deficiency B6 symptoms. It also mentions it was toxic even at lower doses killing cells, and Lareb reported that some found doses as low as 2mg/day caused the same neuropathy symptoms as higher doses.
This product is Pyrodoxal-5-phosphate, the active form which doesnt have any of those issues, and so in my opinion seems to be the better way to supplement vitamin b6 and why I chose it and now avoid pyridoxine as much as I can.
Vitamin B6 in the non active form also needs Magnesium, Zinc, and Vitamin B2 to convert to its active form. As many are low on magnesium, or are under stress which depletes both magnesium and zinc, it seems that many may not be converting Vitamin B6 as well. There are also genetic mutations MTHFR that some may have that can keep the conversion from occuring. Seeking Health is a high quality brand, and this B6 does not have many of the fillers others do. I would buy again anytime I need a standalone B6 supplement. I also use their Seeking Health B Minus which has 20mg P5P with the other B vitamins except B12 and also Folate, which can be added separate as needed.
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50 Count (Pack of 1)
$5.79 ($0.12/Count)
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This item: Seeking Health P-5-P, Pyridoxal-5-Phosphate, P5P to Support Healthy Cognitive Function, Immune System and Metabolism Support, Vegan and Vegetarian (100 Capsules)
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Product Description
At Seeking Health, we believe there is a fundamental step missing, almost 100% of the time, in today’s healthcare system. A consistent focus on treating symptoms, rather than building health, can mean that you cycle in and out of symptoms and “treatment” over and over, sometimes for years.
Our approach is to support and optimize your digestion, reduce environmental exposure and toxic burden and diet optimization so nutrients can flood in and allow our body to do what it does best - Heal.
Potent Bioavailable Vitamin B6*
P-5-P for Hormone Balance and Mood Support*
Vitamin B6 is an essential nutrient that supports numerous functions in your body. It’s needed to metabolize homocysteine, normalize mood, balance hormones, and help you sleep.*
Seeking Health’s P-5-P contains a potent 25 mg of vitamin B6 (1,471% Daily Value) in the active form of P-5-P (pyridoxal 5’-phosphate).*
- Gluten-free high-strength vitamin B6.*
- Homocysteine metabolism support.*
- May help support a healthy mood.*
Who Needs It?
What's In It?
Why Does it Work?
How do I use it?
At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for manufacturing standards before any ingredient is allowed for use. We only use the highest-quality ingredients.
P-5-P is free of GMOs, Gluten, Artificial Colors, Artificial Flavors, Artificial Preservatives, Dairy, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, and Soy.
Active, bioavailable form of vitamin B6.*
P-5-P plays a role in the AADC enzyme. The Aromatic Acid Decarboxylase enzyme regulates the production of both dopamine and serotonin. These are considered the “feel good” neurotransmitters that support a healthy mood.*
How to Enhance
Consider Pulsing
Dr. Ben Lynch recommends using certain supplements based on your need for them. Start with a partial serving and increase slowly over time to the full serving, only if needed. When you start feeling good, consider reducing the serving size, skipping days, or pausing supplementation. Then take again when you feel you need it (stressful day, traveling, chemical exposure, etc.), hence “pulsing.” Work with your qualified healthcare practitioner to determine what’s best for you.
Pairs Well With
Optimal Magnesium, as both P-5-P (vitamin B6) and magnesium work together to support healthy mental wellbeing and hormone balance.* SulfiteX to support sulfite breakdown. High doses of vitamin B6 may increase sulfite production by acting as a cofactor for enzymes in the glutathione pathway.* Phosphatidyl Serine, to further support a healthy response to stress.*
Clean Your Genes
Though supplements may benefit you immensely, they are only one step of your health journey. In his best-selling book, Dirty Genes, Dr. Ben Lynch describes the Clean Genes Protocol. Combining supplements with this protocol may help promote optimal epigenetic health.*
B Complex Plus
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Magnesium Plus
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HomocysteX Plus
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|---|---|---|---|
| Customer Reviews |
724
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249
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662
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| Price | $28.49 | $28.00 | $32.87 |
| Serving Size | 1 Capsule | 1 Capsule | 1 Capsule |
| Total Servings | 100 | 100 | 60 |
| Delivery Method | Capsule | Capsule | Capsule |
| Ingredient Highlights | Low-allergen formula. May help support healthy liver function and metabolism.* | Low-allergen formula. May help support muscle relaxation.* | Low-allergen formula. May help support healthy methylation processes.* |
| Vegetarian | ✓ | ✓ | ✓ |
| Dairy Free | ✓ | ✓ | ✓ |
| Soy Free | ✓ | ✓ | ✓ |
Compare with similar items
This Item  Seeking Health P-5-P, Pyridoxal-5-Phosphate, P5P to Support Healthy Cognitive Function, Immune System and Metabolism Support, Vegan and Vegetarian (100 Capsules) | Recommendations  |  |  |  |  | |
| Price | $20.00 | $21.95 | $16.95 | $17.20 | $14.89 | $8.99 |
| Price Per Unit | $20.00 / Count | $0.09 / Count | $0.07 / Count | $0.29 / Count | $0.07 / Count | $0.07 / Count |
| Delivery | Get it as soon as Saturday, Apr 19 | Get it as soon as Saturday, Apr 19 | Get it as soon as Saturday, Apr 19 | Get it as soon as Saturday, Apr 19 | Get it as soon as Saturday, Apr 19 | Get it as soon as Saturday, Apr 19 |
| Customer Ratings | ||||||
| Sold By | Pattern Products | eSupplements | eSupplements | Pattern. | Piping Rock Health Products | Best~Naturals |
| primary supplement | Vitamin B | Vitamin-b | Vitamin B6 | — | Vitamin B | Vitamin B6 |
| form | Capsule | Capsule | Capsule | Capsule | Tablet | Tablet |
| unit count | 1 | 240 | 240 | 60 | 200 | 120 |
| flavor | Unflavored | Unflavored | Unflavored | Unflavored | Unflavored | Unflavored |
| weight | — | 0.33 pounds | 50 milligrams | — | — | 100 milligrams |
| specific uses | Brain | — | — | Heart | Nutritional Supplement | Nerve |
| serving suggestion | 1 Capsule | 1 capsule | 1 capsule | — | — | 2 tablets |
| ingredients | Vitamin B6 (as pyridoxal 5'-phosphate). Microcrystalline cellulose, HPMC (vegetable capsule), ascorbyl palmitate, and silica. | Vitamin B6 (as pyridoxal-5-phosphate), rice flour, hypromellose (cellulose) | Vitamin B6 (as pyridoxal-5-phosphate), rice flour, hypromellose (cellulose) capsule. | Each serving size (1 capsule) contains: Pyridoxal-5-Phosphate 50 mg. Other ingredients: Microcrystalline cellulose, hydroxypropyl methylcellulose (capsule), ascorbyl palmitate | Please see Ingredients listed above. | P5P, Dicalcium Phosphate, Microcrystalline Cellulose (Vegetable Grade), Croscarmellose Sodium, Stearic Acid, Silicon Dioxide, Vegetable Magnesium Stearate. |
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Gives lasting energy, so take early in the a.m.
The seller did a good job shipping the correct item, in a secure package, & it arrived quickly. I like the capsule size, smaller than a penny, as I have issues swallowing larger pills. Also, one very significant thing I noticed is a ton of energy. I'm not sure if it was this item or 1 of the other supplements I started the same day, but I had so much energy I couldn't sleep. So, no problem, now I just make sure I take it 1st thing in the morning with food, & it helps a lot. I think it must be because my health practitioner said this form of B6 is one of the most absorbable by the body. Another form of B6 I'd been taking for a long time was not being absorbed well by my body & I didn't realize why I was so lethargic & exhausted all the time. But, now that I take this Targeted Support P-5-P, I have more energy. Some advice I would give is to take it as soon as you can after waking up for the day, & take ½ at 1st, and work your way up to a whole capsule once you determine how your body will react to it.
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